Amazon's Ship By Region templates enables sellers to offer different shipping rates per state. These new shipping settings gives merchants much greater flexibility with shipping options. For example, a merchant can offer 2 day shipping in one state or region, but not in the rest of North America. Whereas previously shipping overrides were used to override account level settings, the new Amazon shipping allows you to create up to twenty shipping templates. The templates are assigned on the product level. Read more here.
Please Note: Gift Wrap options will not be sent to Amazon when Ship By Region Templates is enabled. Also, the regular update shipping template service will not update changes to the shipping templates to Seller Central. They should be manually pushed by reposting the item.